Compression Behavior
- Enhances particle bonding during compression, improving overall cohesion.
- Achieves higher hardness without increasing compression force.
Copovidone USP
Copovidone USP
Sale price$35.00 CAD
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Description
Overview
Copovidone (PVP/VA 64) is a highly effective tablet binder used to strengthen tablets for all processing technologies (direct compression, wet and dry granulation, HME). It helps powders lock together under pressure, creating tablets that are firm, smooth, and resistant to breaking, all without needing large amounts in your formula. Because it performs well at low percentages (>10%), it allows you to maintain space for your active ingredients while still achieving reliable tablet integrity.
Copovidone improves hardness, reduces edge chipping, and helps prevent common compression issues like capping or lamination. It blends easily with materials such as MCC, DCP, and other common fillers, making it a dependable choice for a wide range of formulations. When you want strong, consistent tablets without adding extra processing steps, copovidone offers a simple and efficient solution.
Key Benefits ★
These are the key benefits of Copovidone in direct compression blends:
Improves tablet strength
Improves tablet durabilty
Increases compressibility
Helpful for difficult-to-compress actives
Water soluble
Good flowability
Industry Use & Process Flexibility
While copovidone is well known for direct compression, it is also widely used in wet granulation. When dissolved in water or alcohol, it forms a strong binding solution that helps create dense, uniform granules that compress smoothly and hold together under pressure. This makes it a practical option for manufacturers who switch between direct compression and granulation depending on the formula.
It’s also commonly used in chewables, film-coated tablets, and other specialty formats where structure and durability matter. If a blend feels brittle, dusty, or prone to capping, copovidone is often a great choice that brings stability back into the system. Because it performs reliably across different processes, many formulators keep it as a core binder in their excipient lineup.
In addition to its processing flexibility, copovidone is a fully synthetic material and does not contain animal-derived ingredients. It is free from common allergens such as gluten, dairy, soy, and nuts, making it suitable for vegan and vegetarian formulations. Because it is not sourced from animal materials, it can also support halal and kosher manufacturing requirements when handled within compliant facilities.
What to Expect in Use
Below is a practical, in-use view of how Copovidone typically behaves in direct compression blends, focused on real press behavior. The notes highlight compaction response, flow impact, lubrication interactions, and disintegration considerations so you can predict performance and tune variables quickly.
Flow Behavior
- Disperses evenly throughout blend for consistent binding performance.
- Integrates easily with common fillers and excipients.
Lubrication & Ejection Behavior
- Compatible with common lubricants such as magnesium stearate and sodium stearyl fumarate.
- Contributes to smooth, mechanically stable tablets that eject consistently when properly lubricated.
Disintegration Behavior
- Being water soluble, it supports clean tablet breakup and is suitable for dissolving or fast-disintegrating formats.
- Dissolves readily in common granulation solvents, forming a strong, uniform binder solution.
Specifications
| Parameter | Specification |
|---|---|
| Product | Copovidone (PVP/VA 64) |
| CAS number | 25086-89-9 |
| Molecular formula | (C₆H₉NO)ₙ · (C₄H₆O₂)ₘ |
| Appearance | White to off-white hygroscopic powder |
| Physical state | Solid |
| Bulk density (g/mL) | 0.2 – 0.3 g/mL |
| Loss on drying | ≤ 5.0% |
| pH (1% solution) | 3.0 – 7.0 |
| Solubility | Freely soluble in water and ethanol |
| K-Value | 25.2 – 30.6 |
| Vinyl acetate content | 35.3 – 41.4% |
| Peroxide (as H₂O₂) | ≤ 400 ppm |
| Regulatory status | Ph. Eur., USP/NF, JPE, FCC, ChP, E1208 |
| Storage | Room temperature; protect from heat and moisture |
| Packaging | 1 kg, 5 kg, 20 kg bags |
Reviews
FAQs
What is copovidone used for?
Copovidone is primarily used as a tablet binder to improve strength, cohesion, and durability in both pharmaceutical and nutraceutical formulations. It works well in direct compression, wet granulation, dry granulation, and hot melt extrusion.
What is the typical use level in direct compression?
Most direct compression formulas use copovidone at 2–5%. Higher levels may be used in specialized systems or high-load formulations.
How is copovidone different from povidone (PVP)?
Copovidone is a copolymer of vinylpyrrolidone and vinyl acetate. Compared to standard povidone, it is less hygroscopic and often performs better in direct compression systems.
Is copovidone water soluble?
Yes. Copovidone is freely soluble in water and common granulation solvents, making it suitable for wet granulation and fast-disintegrating tablet systems.
Can copovidone be used in wet granulation?
Yes. It dissolves easily in water or alcohol to form a strong binder solution, producing dense, uniform granules that compress smoothly.
Does copovidone improve tablet hardness?
Yes. Copovidone enhances interparticle bonding during compression, often achieving higher hardness at the same compaction force.
Is copovidone suitable for high-dose or poorly compressible actives?
Yes. It is commonly used to strengthen brittle blends and improve compressibility in high-load or difficult-to-compact formulations.
Is copovidone compatible with common lubricants?
Yes. It is compatible with lubricants such as magnesium stearate and sodium stearyl fumarate when used at appropriate levels.
Is copovidone vegan and allergen-free?
Copovidone is fully synthetic and does not contain animal-derived ingredients. It is free from common allergens such as gluten, dairy, soy, and nuts.
How should copovidone be stored?
Store in a tightly closed container, protected from heat and moisture. Avoid prolonged exposure to oxygen to minimize peroxide formation.
Overview
Copovidone (PVP/VA 64) is a highly effective tablet binder used to strengthen tablets for all processing technologies (direct compression, wet and dry granulation, HME). It helps powders lock together under pressure, creating tablets that are firm, smooth, and resistant to breaking, all without needing large amounts in your formula. Because it performs well at low percentages (>10%), it allows you to maintain space for your active ingredients while still achieving reliable tablet integrity.
Copovidone improves hardness, reduces edge chipping, and helps prevent common compression issues like capping or lamination. It blends easily with materials such as MCC, DCP, and other common fillers, making it a dependable choice for a wide range of formulations. When you want strong, consistent tablets without adding extra processing steps, copovidone offers a simple and efficient solution.
Key Benefits ★
These are the key benefits of Copovidone in direct compression blends:
Improves tablet strength
Improves tablet durabilty
Increases compressibility
Helpful for difficult-to-compress actives
Water soluble
Good flowability
Industry Use & Process Flexibility
While copovidone is well known for direct compression, it is also widely used in wet granulation. When dissolved in water or alcohol, it forms a strong binding solution that helps create dense, uniform granules that compress smoothly and hold together under pressure. This makes it a practical option for manufacturers who switch between direct compression and granulation depending on the formula.
It’s also commonly used in chewables, film-coated tablets, and other specialty formats where structure and durability matter. If a blend feels brittle, dusty, or prone to capping, copovidone is often a great choice that brings stability back into the system. Because it performs reliably across different processes, many formulators keep it as a core binder in their excipient lineup.
In addition to its processing flexibility, copovidone is a fully synthetic material and does not contain animal-derived ingredients. It is free from common allergens such as gluten, dairy, soy, and nuts, making it suitable for vegan and vegetarian formulations. Because it is not sourced from animal materials, it can also support halal and kosher manufacturing requirements when handled within compliant facilities.
What to Expect in Use
Below is a practical, in-use view of how Copovidone typically behaves in direct compression blends, focused on real press behavior. The notes highlight compaction response, flow impact, lubrication interactions, and disintegration considerations so you can predict performance and tune variables quickly.
Compression Behavior
- Enhances particle bonding during compression, improving overall cohesion.
- Achieves higher hardness without increasing compression force.
Flow Behavior
- Disperses evenly throughout blend for consistent binding performance.
- Integrates easily with common fillers and excipients.
Lubrication & Ejection Behavior
- Compatible with common lubricants such as magnesium stearate and sodium stearyl fumarate.
- Contributes to smooth, mechanically stable tablets that eject consistently when properly lubricated.
Disintegration Behavior
- Being water soluble, it supports clean tablet breakup and is suitable for dissolving or fast-disintegrating formats.
- Dissolves readily in common granulation solvents, forming a strong, uniform binder solution.
| Parameter | Specification |
|---|---|
| Product | Copovidone (PVP/VA 64) |
| CAS number | 25086-89-9 |
| Molecular formula | (C₆H₉NO)ₙ · (C₄H₆O₂)ₘ |
| Appearance | White to off-white hygroscopic powder |
| Physical state | Solid |
| Bulk density (g/mL) | 0.2 – 0.3 g/mL |
| Loss on drying | ≤ 5.0% |
| pH (1% solution) | 3.0 – 7.0 |
| Solubility | Freely soluble in water and ethanol |
| K-Value | 25.2 – 30.6 |
| Vinyl acetate content | 35.3 – 41.4% |
| Peroxide (as H₂O₂) | ≤ 400 ppm |
| Regulatory status | Ph. Eur., USP/NF, JPE, FCC, ChP, E1208 |
| Storage | Room temperature; protect from heat and moisture |
| Packaging | 1 kg, 5 kg, 20 kg bags |
What is copovidone used for?
Copovidone is primarily used as a tablet binder to improve strength, cohesion, and durability in both pharmaceutical and nutraceutical formulations. It works well in direct compression, wet granulation, dry granulation, and hot melt extrusion.
What is the typical use level in direct compression?
Most direct compression formulas use copovidone at 2–5%. Higher levels may be used in specialized systems or high-load formulations.
How is copovidone different from povidone (PVP)?
Copovidone is a copolymer of vinylpyrrolidone and vinyl acetate. Compared to standard povidone, it is less hygroscopic and often performs better in direct compression systems.
Is copovidone water soluble?
Yes. Copovidone is freely soluble in water and common granulation solvents, making it suitable for wet granulation and fast-disintegrating tablet systems.
Can copovidone be used in wet granulation?
Yes. It dissolves easily in water or alcohol to form a strong binder solution, producing dense, uniform granules that compress smoothly.
Does copovidone improve tablet hardness?
Yes. Copovidone enhances interparticle bonding during compression, often achieving higher hardness at the same compaction force.
Is copovidone suitable for high-dose or poorly compressible actives?
Yes. It is commonly used to strengthen brittle blends and improve compressibility in high-load or difficult-to-compact formulations.
Is copovidone compatible with common lubricants?
Yes. It is compatible with lubricants such as magnesium stearate and sodium stearyl fumarate when used at appropriate levels.
Is copovidone vegan and allergen-free?
Copovidone is fully synthetic and does not contain animal-derived ingredients. It is free from common allergens such as gluten, dairy, soy, and nuts.
How should copovidone be stored?
Store in a tightly closed container, protected from heat and moisture. Avoid prolonged exposure to oxygen to minimize peroxide formation.
Resource
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